Demi Moore gives a career-best performance as Elisabeth Sparkle, a former A-lister past her prime and suddenly fired from her fitness TV show by repellent studio head Harvey (Dennis Quaid).

She is then drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE. All it takes is one injection and she is reborn – temporarily – as the gorgeous, twentysomething Sue (Margaret Qualley). The only rule? Time needs to be split: exactly one week in one body, then one week in the other. No exceptions. A perfect balance. What could go wrong?

Explosive, provocative and twisted, The Substance marks the arrival of a thrillingly visionary filmmaker.

This film contains flickering or flashing lights that may affect those with photosensitive epilepsy.

"Some will run screaming, but if it’s your jam, this could just be your new favourite horror movie." Time Out